Cosmetogenomics

The Importance of Cosmetogenomics Analysis

Compliance with the regulation of your target market is a key step in order to ensure you gain timely and full market access.

Cosmetogenomic analysis allows the response of the human genome to be studied (quantification of the expression of all the genes in the human genome), which reflects physiological or pathological conditions, as well as the effects of a treatment. After RNA extraction/validation from skin explants, cell lines, primary cells or reconstructed epidermis, cosmetogenomics helps to screen raw materials or to evaluate the efficacy of finished products through gene expression profile analysis.

PredictSearch® functional analysis, towards defining the biological effects in which the modulated genes/proteins are involved, brings scientific basis for allegations necessary to any claims.

Cosmetogenomics: when the science of genes reveals the secrets of your cosmetics

Eurofins offers comprehensive, quality-driven genomic services that expedite the translation of basic research into cosmetics and nutraceutical product development.

Adapted biological models for DNA/RNA/miRNA extraction

• In vitro (2D cell cultures, keratinocytes, fibroblasts, melanocytes, etc.)
• Ex vivo (skin explants, adipose tissue, scalp, isolated hairs, etc.)
• FFPE samples
• In vivo (skin microbiota, tape strips)

Tissue challenges

• UV irradiations
• Blue light
• Pollutants
• Pollen exposure
• Wound methods
• And more

Custom technical solutions

• DNA microarray
• miRNA microarray
• qPCR-gold standards
• PCRarray- Flexible, customisable, etc.

Eurofins Cosmetics & Personal Care provides all its expertise for your personal care and nutrition projects.

Discover the new molecular signature of your active ingredients

Identify biological mechanisms of your ingredient

Develop high-performance, innovative products

Streamline product development cost

Enhance clinical studies

Innovative genomic data analysis tools

PredictSearch™

PredictSearch™ is a powerful text mining software for big data analysis that searches and retrieves correlations between genes and biological processes/pathologies in all PubMed scientific publications, citing at least one gene or one of its aliases. The transcriptomic study with PredictSearch™ allows us to:

• Highlightall the biological effects of evaluated ingredient/end product in a single analysis
• Reveal any cytotoxicity
• Identify new mechanisms of action for innovation, new allegations and repositioning of ingredients
• Communicate based on a solid scientific

ActiveSearch™

ActiveSearch™ is based on a multidimensional matrix, allowing correlations among or within the five database « AllSource », « AllGene », « AllProcess», « AllConcept », « AllTissue ». The « AllSource » database containing the « plants-vegetal extract/fungus/bacteria/algae » elements identifies, for a given input, the bibliographic references, as well as the connections between other input from the same database. ActiveSearch™ provides:

• In silico research of actives or plant extract of interest
• Bibliographic investigations
• The ability to strengthen your intellectual property

Scientific support

• Bring to light the impact of nutrition or environmental factors on human skin physiology and thus understand their mechanism of action
• Strengthen your intellectual property through the identification of new fields of applications for claim substantiation
• Decrease risks through the characterisation of potential cytotoxic activities
• Support claims: integration of scientific studies to support nutritional, nutricosmetics and cosmeceutical claims
• Reposition your products based on new claims
• Design premarketing reports based on scientific results.